The first vessel ever to have been sunk by a guided air-launched weapon was HMS Egret in the Bay of Biscay 1943, some 38 miles off Vigo.
198 crew, including 4 RAF signallers, were killed that day.
Spirit of Remembrance have now managed to arrange funding to ensure that a 97 year old widow of one of the crew, together with her family, are making a visit to the location of the sinking between 25-30 August 2012.
Looks like an interesting and very poignant tour. I believe there are still spaces available.